Forecasts by Application, Technology, Product and Place. With Executive and Consultant Guides. 2024 to 2028"
Howe Sound Research Published February 2024 – 303 pages
Where genomics can’t find all the answers proteomics is stepping up to the plate.
Who will be the Illumina of Proteomics? Will these new biomarkers redefine disease definitions? Will Proteomic Assays displace current Genomic Assays? Find out all about it and more in this comprehensive report.
Proteomic Biomarker Analytics is just finding its feet, but the opportunity is huge. Players are reporting double digit growth. Venture capital is well involved. Learn about this market including the issues and outlooks. This technology could possibly displace most cancer diagnostic protocols AND save money at the same time. The report forecasts the market size out for five years for a number of different market segments.
All report data is available in Excel format on request.
Your report is provided on a 12-month subscription basis from the date you receive your first report. You will receive 2 or more updated versions of the complete report during the 12 months. At least one of these updates will provide forecasts based on next year’s data.
Table of Contents
1 Market Guides …………………………………………………………………………………………………… 15
1.1 Situation Analysis ……………………………………………………………………………………………….. 16
1.2 Guide for Executives and Marketing Staff …………………………………………………………… 18
1.3 Guide for Investment Analysts and Management Consultants …………………………….. 19
2 Introduction and Market Definition …………………………………………………………………….. 20
2.1 What is Proteomic Biomarker Analytics? ……………………………………………………………… 21
2.2 Proteomics and Drug Development …………………………………………………………………… 22
2.3 Market Definition ……………………………………………………………………………………………….. 23
2.3.1 Market Size …………………………………………………………………………………………………….. 23
2.3.2 Currency ……………………………………………………………………………………………………….. 23
2.3.3 Years ……………………………………………………………………………………………………………… 23
2.4 Methodology …………………………………………………………………………………………………….. 24
2.4.1 Methodology …………………………………………………………………………………………………. 24
2.4.2 Sources ………………………………………………………………………………………………………….. 24
2.4.3 Authors ………………………………………………………………………………………………………….. 24
3 Proteomic Biomarker Analytics – Guide to Technologies …………………………… 26
3.1 Methods ……………………………………………………………………………………………………………. 27
3.1.1 Separation techniques and electrophoresis …………………………………………………….. 27
3.1.2 Mass spectrometry …………………………………………………………………………………………. 27
3.1.3 Chromatography …………………………………………………………………………………………… 28
3.1.4 Blotting ………………………………………………………………………………………………………….. 28
3.1.5 Protein complementation assays and interaction screens ……………………………….. 28
3.1.6 Protein structure prediction …………………………………………………………………………….. 28
3.1.7 Protein databases ………………………………………………………………………………………….. 29
4 Industry Overview ………………………………………………………………………………………………. 30
4.1 Players in a Dynamic Market ………………………………………………………………………………. 31
4.2 Academic Research Lab …………………………………………………………………………………… 32
4.3 Diagnostic Test Developer ………………………………………………………………………………….. 32
4.4 Instrumentation Supplier …………………………………………………………………………………….. 33
4.5 Chemical/Reagent Supplier ………………………………………………………………………………. 33
4.6 Pathology Supplier …………………………………………………………………………………………….. 33
4.7 Independent Clinical Laboratory ……………………………………………………………………….. 33
4.8 Public National/regional Laboratory …………………………………………………………………… 34
4.9 Hospital Laboratory ……………………………………………………………………………………………. 34
4.10 Physicians Office Lab (POLS) ………………………………………………………………………………. 35
4.11 Audit Body ………………………………………………………………………………………………………… 35
4.12 Certification Body ……………………………………………………………………………………………… 36
5 Market Trends ……………………………………………………………………………………………………. 37
5.1 Factors Driving Growth ………………………………………………………………………………………. 38
5.1.1 Drug Development ………………………………………………………………………………………… 38
5.1.2 Companion Dx ………………………………………………………………………………………………. 39
5.1.3 Fertile Research ……………………………………………………………………………………………… 39
5.1.4 Technology Convergence ……………………………………………………………………………… 39
5.2 Factors Limiting Growth ……………………………………………………………………………………… 40
5.2.1 The Cost Curve ………………………………………………………………………………………………. 40
5.2.2 Capacity Constraints ……………………………………………………………………………………… 40
5.2.3 Market Lag …………………………………………………………………………………………………….. 41
6 Proteomic Analytics Recent Developments ………………………………………………………… 42
6.1 Recent Developments – Importance and How to Use This Section ………………………. 43
6.1.1 Importance of These Developments ……………………………………………………………….. 43
6.1.2 How to Use This Section …………………………………………………………………………………… 43
6.2 Mass Spec Test to Detect Ovarian Cancer …………………………………………………………. 43
6.3 Proteomic Multiple Sclerosis Test Gaining Traction ……………………………………………….. 46
6.4 Emory U Protein Panel Could Diagnose Alzheimer’s Disease…………………………………. 50
6.5 Amprion’s Parkinson’s Disease Dx Shows Strong Performance ………………………………. 52
6.6 Single-Cell Proteomics Bypasses Bottlenecks ……………………………………………………….. 55
6.7 SomaLogic Seeks ‘Strategic Alternatives’ for Dx Business ………………………………………. 60
6.8 Alzheimer’s Dx Study to Add Genomic, Proteomic Profiling ………………………………….. 61
6.9 NanoDx Prepares for POC Platform Commercialization ………………………………………. 64
6.10 DeepMind AI Predicts 3D Structure of Every Protein …………………………………………….. 67
6.11 Quanterix Slashing Workforce by 25 Percent ……………………………………………………….. 70
6.12 Study Shows Potential of NanoMosaic’s Platform for Biomarker Development ………. 71
6.13 Exact Sciences Bolsters Plasma Proteomics Tech With $15M Purchase of OmicEra .. 74
6.14 PrognomiQ Exploring Multiomic Markers for Variety of Cancer Dx Applications ……. 78
6.15 Octave Bioscience Building Evidence Base for Multiple Sclerosis Test …………………… 80
6.16 Proteomics Goes Public ……………………………………………………………………………………… 82
7 Profiles of Key Proteomic Biomarker Analytic Companies………………………….. 87
7.1 Abbott Laboratories …………………………………………………………………………………………… 88
7.2 Abcam ……………………………………………………………………………………………………………… 89
7.3 Agilent ………………………………………………………………………………………………………………. 90
7.4 Amprion ……………………………………………………………………………………………………………. 91
7.5 ATUM ………………………………………………………………………………………………………………… 92
7.6 BasePair Biotechnologies …………………………………………………………………………………… 93
7.7 Beckman Coulter Diagnostics (Danaher) ……………………………………………………………. 94
7.8 Becton, Dickinson and Company ………………………………………………………………………. 95
7.9 Biomatik …………………………………………………………………………………………………………….. 96
7.10 Bio-Rad Laboratories, Inc……………………………………………………………………………………. 97
7.11 Bio-Techne ………………………………………………………………………………………………………… 98
7.12 Bruker ………………………………………………………………………………………………………………… 99
7.13 C2N Diagnostics ………………………………………………………………………………………………. 100
7.14 Cepheid (Danaher) …………………………………………………………………………………………. 101
7.15 Diadem Diagnostics …………………………………………………………………………………………. 102
7.16 Eve Technologies …………………………………………………………………………………………….. 103
7.17 Fujirebio …………………………………………………………………………………………………………… 104
7.18 Hybrigenics Services …………………………………………………………………………………………. 105
7.19 MRM Proteomics Inc. ……………………………………………………………………………………….. 106
7.20 NanoDx …………………………………………………………………………………………………………… 107
7.21 Nautilus Biotechnology …………………………………………………………………………………….. 108
7.22 Nicoya …………………………………………………………………………………………………………….. 109
7.23 Nuclera …………………………………………………………………………………………………………… 110
7.24 Olink ………………………………………………………………………………………………………………… 112
7.25 Qiagen ……………………………………………………………………………………………………………. 113
7.26 Quanterix ………………………………………………………………………………………………………… 114
7.27 Roche Diagnostics …………………………………………………………………………………………… 115
7.28 Second Genome …………………………………………………………………………………………….. 116
7.29 Siemens Healthineers ……………………………………………………………………………………….. 117
7.30 Sphingotec ……………………………………………………………………………………………………… 118
7.31 Thermo Fisher Scientific …………………………………………………………………………………….. 119
7.32 Unchained Labs ………………………………………………………………………………………………. 120
8 Global Proteomic Analytics Markets …………………………………………………………………. 121
8.1 PROTEIN ANALYTICS – Global Market Overview by Country ……………………………….. 122
8.1.1 Table – Global Market by Country …………………………………………………………………. 122
8.1.2 Chart – Global Market by Country …………………………………………………………………. 123
8.2 Global Market by Application – Overview …………………………………………………………. 124
8.2.1 Table – Global Market by Application …………………………………………………………… 124
8.2.2 Chart – Global Market by Application – Segments Growth …………………………….. 125
8.2.3 Chart – Global Market by Application – Base/Final Comparison …………………….. 126
8.2.4 Chart – Global Market by Application – Base Year ………………………………………… 127
8.2.5 Chart – Global Market by Application – Final Year …………………………………………. 128
8.2.6 Chart – Global Market by Application – Share by Year …………………………………… 129
8.3 Global Market by Technology – Overview …………………………………………………………. 130
8.3.1 Table – Global Market by Technology …………………………………………………………… 130
8.3.2 Chart – Global Market by Technology – Segments Growth …………………………….. 131
8.3.3 Chart – Global Market by Technology – Base/Final Comparison …………………….. 132
8.3.4 Chart – Global Market by Technology – Base Year ………………………………………… 133
8.3.5 Chart – Global Market by Technology – Final Year …………………………………………. 134
8.3.6 Chart – Global Market by Technology – Share by Year…………………………………… 135
8.4 Global Market by Product – Overview ………………………………………………………………. 136
8.4.1 Table – Global Market by Product …………………………………………………………………. 136
8.4.2 Chart – Global Market by Product – Segments Growth ………………………………….. 137
8.4.3 Chart – Global Market by Product – Base/Final Comparison …………………………… 138
8.4.4 Chart – Global Market by Product – Base Year ………………………………………………. 139
8.4.5 Chart – Global Market by Product – Final Year ………………………………………………. 140
8.4.6 Chart – Global Market by Product – Share by Year ………………………………………… 141
8.5 Global Market by Place – Overview ………………………………………………………………….. 142
8.5.1 Table – Global Market by Place …………………………………………………………………….. 142
8.5.2 Chart – Global Market by Place – Segments Growth ……………………………………… 143
8.5.3 Chart – Global Market by Place – Base/Final Comparison ……………………………… 144
8.5.4 Chart – Global Market by Place – Base Year………………………………………………….. 145
8.5.5 Chart – Global Market by Place – Final Year ………………………………………………….. 146
8.5.6 Chart – Global Market by Place – Share by Year ……………………………………………. 147
9 Global PROTEIN ANALYTICS Markets – By Application ………………………………………… 148
9.1 PROTEIN ANALYTICS Drug Discovery ………………………………………………………………….. 149
9.1.1 Table PROTEIN ANALYTICS Drug Discovery – by Country …………………………………. 149
9.1.2 Chart – PROTEIN ANALYTICS Drug Discovery Growth ………………………………………. 150
9.2 PROTEIN ANALYTICS Research Application ………………………………………………………… 151
9.2.1 Table PROTEIN ANALYTICS Research Application – by Country ……………………….. 151
9.2.2 Chart – PROTEIN ANALYTICS Research Application Growth …………………………….. 152
9.3 PROTEIN ANALYTICS Clinical Dx …………………………………………………………………………. 153
9.3.1 Table PROTEIN ANALYTICS Clinical Dx – by Country ………………………………………… 153
9.3.2 Chart – PROTEIN ANALYTICS Clinical Dx Growth ……………………………………………… 154
9.4 PROTEIN ANALYTICS Other Applications ……………………………………………………………. 155
9.4.1 Table PROTEIN ANALYTICS Other Applications – by Country ……………………………. 155
9.4.2 Chart – PROTEIN ANALYTICS Other Applications Growth …………………………………. 156
10 Global PROTEIN ANALYTICS Markets – By Technology ……………………………………. 157
10.1 PROTEIN ANALYTICS Mass Spectrometry ……………………………………………………………. 158
10.1.1 Table PROTEIN ANALYTICS Mass Spectrometry – by Country………………………… 158
10.1.2 Chart – PROTEIN ANALYTICS Mass Spectrometry Growth ……………………………… 159
10.2 PROTEIN ANALYTICS ELISA/Beads ………………………………………………………………………. 160
10.2.1 Table PROTEIN ANALYTICS ELISA/Beads – by Country ………………………………….. 160
10.2.2 Chart – PROTEIN ANALYTICS ELISA/Beads Growth ………………………………………… 161
10.3 PROTEIN ANALYTICS Hybrid Multiplex…………………………………………………………………. 162
10.3.1 Table PROTEIN ANALYTICS Hybrid Multiplex – by Country …………………………….. 162
10.3.2 Chart – PROTEIN ANALYTICS Hybrid Multiplex Growth ………………………………….. 163
10.4 PROTEIN ANALYTICS Other Technology ……………………………………………………………… 164
10.4.1 Table PROTEIN ANALYTICS Other Technology – by Country …………………………. 164
10.4.2 Chart – PROTEIN ANALYTICS Other Technology Growth ……………………………….. 165
11 Global PROTEIN ANALYTICS Markets – By Product …………………………………………. 166
11.1 PROTEIN ANALYTICS Instruments ……………………………………………………………………….. 167
11.1.1 Table PROTEIN ANALYTICS Instruments – by Country ……………………………………. 167
11.1.2 Chart – PROTEIN ANALYTICS Instruments Growth …………………………………………. 168
11.2 PROTEIN ANALYTICS Kits & Reagents …………………………………………………………………. 169
11.2.1 Table PROTEIN ANALYTICS Kits & Reagents – by Country ……………………………… 169
11.2.2 Chart – PROTEIN ANALYTICS Kits & Reagents Growth …………………………………… 170
11.3 PROTEIN ANALYTICS Services …………………………………………………………………………….. 171
11.3.1 Table PROTEIN ANALYTICS Services – by Country ………………………………………… 171
11.3.2 Chart – PROTEIN ANALYTICS Services Growth ………………………………………………. 172
12 Global PROTEIN ANALYTICS Markets – By Place …………………………………………….. 173
12.1 PROTEIN ANALYTICS Academic ………………………………………………………………………… 174
12.1.1 Table PROTEIN ANALYTICS Academic – by Country …………………………………….. 174
12.1.2 Chart – PROTEIN ANALYTICS Academic Growth ………………………………………….. 175
12.2 PROTEIN ANALYTICS Pharma/Biotech ………………………………………………………………… 176
12.2.1 Table PROTEIN ANALYTICS Pharma/Biotech – by Country ……………………………. 176
12.2.2 Chart – PROTEIN ANALYTICS Pharma/Biotech Growth …………………………………. 177
12.3 PROTEIN ANALYTICS Clinical ……………………………………………………………………………… 178
12.3.1 Table PROTEIN ANALYTICS Clinical – by Country …………………………………………. 178
12.3.2 Chart – PROTEIN ANALYTICS Clinical Growth ……………………………………………….. 179
12.4 PROTEIN ANALYTICS Other Place ………………………………………………………………………. 180
12.4.1 Table PROTEIN ANALYTICS Other Place – by Country ………………………………….. 180
12.4.2 Chart – PROTEIN ANALYTICS Other Place Growth ………………………………………… 181
13 Appendices ………………………………………………………………………………………………… 182
13.1 Clinical Laboratory Fee Schedule……………………………………………………………………… 183
13.2 The Most Used IVD Assays …………………………………………………………………………………. 291
13.3 The Highest Grossing Assays ……………………………………………………………………………… 296
13.4 The Changing IVD Menu ………………………………………………………………………………….. 301
13.4.1 Approved IVD Test Menu History ………………………………………………………………… 301
13.5 The Changing Picture on Reimbursement …………………………………………………………. 302
Table of Tables
Table 1 Market Players by Type ……………………………………………………………………………………….. 32
Table 2 Five Factors Driving Growth ………………………………………………………………………………….. 38
Table 3 Three Factors Limiting Growth ………………………………………………………………………………. 40
Table 4 Market Size by Country ………………………………………………………………………………………. 122
Table 5 Global Market by Application ……………………………………………………………………………. 124
Table 6 Global Market by Technology ……………………………………………………………………………. 130
Table 7 Global Market by Product ………………………………………………………………………………….. 136
Table 8 Global Market by Place ……………………………………………………………………………………… 142
Table 9 PROTEIN ANALYTICS Drug Discovery by Country …………………………………………………. 149
Table 10 PROTEIN ANALYTICS Research Application by Country ………………………………………. 151
Table 11 PROTEIN ANALYTICS Clinical Dx by Country ……………………………………………………….. 153
Table 12 PROTEIN ANALYTICS Other Applications by Country …………………………………………… 155
Table 13 PROTEIN ANALYTICS Mass Spectrometry by Country …………………………………………. 158
Table 14 PROTEIN ANALYTICS Hybrid Multiplex by Country ……………………………………………….. 162
Table 15 PROTEIN ANALYTICS Other Technology by Country ……………………………………………. 164
Table 16 PROTEIN ANALYTICS Instruments by Country ……………………………………………………… 167
Table 17 PROTEIN ANALYTICS Kits & Reagents by Country ………………………………………………… 169
Table 18 PROTEIN ANALYTICS Services by Country …………………………………………………………… 171
Table 19 PROTEIN ANALYTICS Academic by Country ………………………………………………………. 174
Table 20 PROTEIN ANALYTICS Pharma/Biotech by Country ………………………………………………. 176
Table 21 PROTEIN ANALYTICS Clinical by Country ……………………………………………………………. 178
Table 22 PROTEIN ANALYTICS Other Place by Country …………………………………………………….. 180
Table 23 Clinical Lab Fee Schedule ………………………………………………………………………………… 183
Table 24 The Most Common Assays ……………………………………………………………………………….. 291
Table 25 Largest Revenue Assays ……………………………………………………………………………………. 296
Table of Figures
Figure 1 The Road to Diagnostics ……………………………………………………………………………………… 31
Figure 2 Base year Global Market Share Chart ………………………………………………………………… 123
Figure 3 PROTEIN ANALYTICS Market by Application – Segments Growth …………………………. 125
Figure 4 PROTEIN ANALYTICS Market by Application – Base vs. final …………………………………. 126
Figure 5 PROTEIN ANALYTICS Market Base year ……………………………………………………………….. 127
Figure 6 PROTEIN ANALYTICS Market Final Year ……………………………………………………………….. 128
Figure 7 PROTEIN ANALYTICS Application Share by Year ………………………………………………….. 129
Figure 8 PROTEIN ANALYTICS Market by Technology – Segments Growth …………………………. 131
Figure 9 PROTEIN ANALYTICS Market by Technology – Base vs. final …………………………………. 132
Figure 10 PROTEIN ANALYTICS Market by Technology Base year ………………………………………. 133
Figure 11 PROTEIN ANALYTICS Market by Technology Final Year ………………………………………. 134
Figure 12 PROTEIN ANALYTICS Technology Share by Year ………………………………………………… 135
Figure 13 PROTEIN ANALYTICS Market by Product – Segments Growth ……………………………… 137
Figure 14 PROTEIN ANALYTICS Market by Product – Base vs. final ……………………………………… 138
Figure 15 PROTEIN ANALYTICS Market by Product Base year ……………………………………………. 139
Figure 16 PROTEIN ANALYTICS Market by Product Final Year…………………………………………….. 140
Figure 17 Product Share by Year …………………………………………………………………………………….. 141
Figure 18 PROTEIN ANALYTICS Market by Place – Segments Growth …………………………………. 143
Figure 19 PROTEIN ANALYTICS Market by Place – Base vs. final …………………………………………. 144
Figure 20 PROTEIN ANALYTICS Market by Place Base year ……………………………………………….. 145
Figure 21 PROTEIN ANALYTICS Market by Place Final Year ……………………………………………….. 146
Figure 22 Place Share by Year ………………………………………………………………………………………… 147
Figure 23 PROTEIN ANALYTICS Drug Discovery Growth …………………………………………………….. 150
Figure 24 PROTEIN ANALYTICS Research Application Growth …………………………………………… 152
Figure 25 PROTEIN ANALYTICS Clinical Dx Growth ……………………………………………………………. 154
Figure 26 PROTEIN ANALYTICS Other Applications Growth ……………………………………………….. 156
Figure 27 PROTEIN ANALYTICS Mass Spectrometry Growth ……………………………………………….. 159
Figure 28 PROTEIN ANALYTICS ELISA/Beads Growth …………………………………………………………. 161
Figure 29 PROTEIN ANALYTICS Hybrid Multiplex Growth ……………………………………………………. 163
Figure 30 PROTEIN ANALYTICS Other Technology Growth ………………………………………………… 165
Figure 31 PROTEIN ANALYTICS Instruments Growth …………………………………………………………… 168
Figure 32 PROTEIN ANALYTICS Kits & Reagents Growth …………………………………………………….. 170
Figure 33 PROTEIN ANALYTICS Services Growth ……………………………………………………………….. 172
Figure 34 PROTEIN ANALYTICS Academic Growth ……………………………………………………………. 175
Figure 35 PROTEIN ANALYTICS Pharma/Biotech Growth …………………………………………………… 177
Figure 36 PROTEIN ANALYTICS Clinical Growth ………………………………………………………………… 179
Figure 37 PROTEIN ANALYTICS Other Place Growth………………………………………………………….. 181
Figure 38 The Growing Menu of Approved Assays …………………………………………………………… 301
Figure 39 The Changing Reimbursement Picture ……………………………………………………………… 302
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