Forecasts by Technology, Product and Application. With Executive and Consultant Guides. 2025 to 2029
Howe Sound Research Published November 2024 – 405 pages
“Immuno-oncology frontier and liquid biopsy combine to create enormous new market demand.…”
Flow Cytometry is a mainstay of analytical methods to study cells, but growth is now accelerating as new immuno-oncology and liquid biopsy markets create unprecedented investment in the race to cure cancer. Research vs. Clinical, Bead vs. Gel, its all here in this comprehensive report.
On top of this new genome based knowledge is fostering a new generation of scientific exploration of single cells. This market just keeps on growing with no end in sight. The workhorse of the pharmaceutical industry is becoming a central player in biotechnology.
This is a complex area but this readable report will bring the entire management team up to speed, on both the technology and the opportunity.
The technology is moving faster than the market. Find the opportunities and the pitfalls. Understand growth expectations and the ultimate potential market size.
Your report is provided on a 12-month subscription basis from the date you receive your first report. You will receive 2 or more updated versions of the complete report during the 12 months. At least one of these updates will provide forecasts based on next year’s data.
1 Market Guides ………………………………………………………………………….. 19
1.1 Situation Analysis ……………………………………………………………………….. 20
1.2 Guide for Executives and Marketing Staff …………………………………. 23
1.3 Guide for Investment Analysts and Management Consultants ….. 24
2 Introduction and Market Definition …………………………………………… 25
2.1 What is Flow Cytometry? …………………………………………………………… 26
2.1.1 Cell Sorting ………………………………………………………………………….. 27
2.1.2 Academic Use …………………………………………………………………….. 28
2.2 Market Definition ………………………………………………………………………. 30
2.2.1 Market Size. …………………………………………………………………………. 30
2.2.2 Currency. …………………………………………………………………………….. 30
2.2.3 Years. ………………………………………………………………………………….. 30
2.3 Methodology ……………………………………………………………………………. 32
2.3.1 Methodology ………………………………………………………………………. 32
2.3.2 Sources ……………………………………………………………………………….. 32
2.3.3 Authors ………………………………………………………………………………… 32
2.4 U.S. Medical Market and Pharmceutical Research Spending –
Perspective ………………………………………………………………………………………… 34
2.4.1 U.S. Expenditures for Pharmaceutical Research …………………… 34
3 Flow Cytometry – Guide to Technology ……………………………………. 35
3.1 Flow Cytometers ……………………………………………………………………….. 36
3.2 Hardware ………………………………………………………………………………….. 38
3.2.1 Fluidics …………………………………………………………………………………. 38
3.2.1.1 Hydrodynamic Focusing ………………………………………………… 38
3.2.1.2 Acoustic Focusing ………………………………………………………….. 38
3.2.2 Optics and electronics ………………………………………………………… 38
3.2.2.1 Optical filters ………………………………………………………………….. 39
3.2.2.2 Prisms, gratings, and spectral flow cytometry …………………. 39
3.2.2.3 Imaging flow cytometry …………………………………………………. 39
3.3 Data analysis …………………………………………………………………………….. 40
3.3.1 Compensation …………………………………………………………………….. 40
3.3.2 Gating …………………………………………………………………………………. 40
3.3.3 Computational analysis ……………………………………………………….. 41
3.3.4 FMO controls ……………………………………………………………………….. 42
3.4 Cell Sorting………………………………………………………………………………… 43
3.5 Labels ……………………………………………………………………………………….. 44
3.5.1 Fluorescent labels ………………………………………………………………… 44
3.5.2 Quantum dots …………………………………………………………………….. 44
3.5.3 Isotope labeling …………………………………………………………………… 45
3.6 Bead Array ……………………………………………………………………………….. 46
3.7 Impedance flow cytometry ………………………………………………………. 47
3.8 Flow Cytometry Applications …………………………………………………….. 48
3.9 Cell Viability Assays …………………………………………………………………… 49
3.10 Cell Proliferation Assays ………………………………………………………….. 51
3.11 Cytotoxicity Assays …………………………………………………………………. 53
3.12 Cell Senescence Assays …………………………………………………………. 54
3.13 Apoptosis ……………………………………………………………………………….. 55
3.14 Autophagy …………………………………………………………………………….. 56
3.15 Necrosis ………………………………………………………………………………….. 57
3.16 Oxidative Stress ………………………………………………………………………. 58
3.17 Signalling Pathways, GPCR …………………………………………………….. 61
3.18 Immune Regulation & Inhibition ……………………………………………… 63
3.19 Reporter Gene Technology ……………………………………………………. 64
4 Industry Overview …………………………………………………………………….. 65
4.1 Players in a Dynamic Market …………………………………………………….. 66
4.1.1 Academic Research Lab …………………………………………………….. 67
4.1.2 Contract Research Organization …………………………………………. 67
4.1.3 Genomic Instrumentation Supplier ………………………………………. 68
4.1.4 Cell Separation and Viewing Supplier ………………………………….. 68
4.1.5 Cell Line and Reagent Supplier ……………………………………………. 68
4.1.6 Pharmaceutical Company ………………………………………………….. 69
4.1.7 Audit Body …………………………………………………………………………… 69
4.1.8 Certification Body ……………………………………………………………….. 69
5 Market Trends …………………………………………………………………………… 71
5.1 Factors Driving Growth ……………………………………………………………… 72
5.1.1 The Move to Cell Based Analytics ………………………………………… 73
5.1.2 Immuno-oncology ………………………………………………………………. 73
5.1.3 Genomic Blizzard …………………………………………………………………. 75
5.1.4 Technology Convergence…………………………………………………… 76
5.2 Factors Limiting Growth …………………………………………………………….. 77
5.2.1 Genomic Technology Competition……………………………………… 77
5.2.2 Instrument Integration …………………………………………………………. 78
5.2.3 Maturity ……………………………………………………………………………….. 78
5.3 Technology Development ………………………………………………………… 79
5.3.1 Software ……………………………………………………………………………… 79
5.3.2 Instrument Size …………………………………………………………………….. 79
5.3.3 Larger Panels ………………………………………………………………………. 80
5.3.4 The Next Five Years ……………………………………………………………… 80
6 Flow Cytometry Recent Developments ……………………………………. 81
6.1 Recent Developments – Importance and How to Use This Section
82
6.1.1 Importance of These Developments ……………………………………. 82
6.1.2 How to Use This Section ……………………………………………………….. 82
6.2 CyPath® Lung Cancer Test Supports Flow Cytometry Guidelines . 82
6.3 Flow Cytometry Usedto Study MRD …………………………………………… 84
6.4 Light-field flow cytometry for multiparametric 3D single-cell
analysis ………………………………………………………………………………………………. 85
6.5 Virax Biolabs Partners for Long COVID Study ……………………………… 86
6.6 Agilent Aims for Early-Stage CDx Development Deals ……………….. 87
6.7 Navigate BioPharma Services To Collaborate with BD ………………. 91
6.8 bioAffinity Technologies Acquires Assets of Precision Pathology
Services ……………………………………………………………………………………………… 94
6.9 Bio-Rad enhances flow cytometry capabilities …………………………. 96
6.10 BD Launches New Robotic System …………………………………………. 98
6.11 Hybrid Flow Cytometer …………………………………………………………… 99
6.12 BD and A*STAR collaborate ……………………………………………………. 99
6.13 Cytek Biosciences to Acquire Flow Cytometry Business ………… 102
6.14 METAFORA Launches a Digital Cytometry Analysis Platform …. 103
6.15 In Vitro Potency Assays Utilize Flow Cytometry ………………………. 104
6.16 Celerion to Offer Molecular and Cell Biology Testing ……………. 107
6.17 Beckman Coulter launches Cytobank v10 Platform ……………… 108
6.18 NASA Deploys Flow Cytometer in Space ………………………………. 110
6.19 BD, Labcorp to Develop Flow Cytometry-Based Companion
Diagnostics ………………………………………………………………………………………. 112
6.20 Slingshot Biosciences Partners With Cambridge Bioscience to
Distribute Synthetic Cells …………………………………………………………………… 113
6.21 Canopy Bio Targeting High-Throughput Spatial Proteomics ….. 114
6.22 Becton Dickinson Advancing Rapid Image-Based Cell Sorting
Tech 119
6.23 Insightful Science Acquires Data Science Company Omiq ….. 122
6.24 Single-Cell Startup Nodexus Raises $30M ………………………………. 123
6.25 Bio-Rad Laboratories StarBright UltraViolet 400 Dye for Flow
Cytometry ………………………………………………………………………………………… 124
6.26 Cytek Biosciences Acquires Cell Analysis Business of Tonbo
Biosciences ………………………………………………………………………………………. 124
6.27 Becton Dickinson FACSymphony A5 SE Cell Analyzer …………… 125
6.28 Biotium ExoBrite EV Membrane Staining Kits ………………………….. 126
6.29 Cytek Biosciences Prices $200M Initial Public Offering …………… 126
6.30 Invivoscribe 12-Color Flow Cytometry Service ………………………. 127
6.31 Beckman Coulter launches CytoFLEX SRT benchtop cell sorter
128
6.32 Thermo Fisher Acquires Cell Sorting Technology From Propel Labs
129
6.33 Thermo Fisher Acquires Programmable Dye Platform Pioneer
Phitonex …………………………………………………………………………………………… 130
6.34 NGS Bests Flow Cytometry for MRD-Based Prediction ……………. 131
6.35 Bio-Rad Launches New StarBright Dyes ………………………………… 134
6.36 Cytek Biosciences Closes $120M Financing Round ……………….. 135
6.37 Cellular Analytics Detects Early Mesothelioma Using Liquid Biopsy
135
6.38 Cytek Biosciences Gets CE Mark for Flow Cytometer ……………. 142
6.39 Aigenpulse launches suite to automate flow cytometry ……….. 142
6.40 Sysmex Partec to Distribute De Novo Flow Cytometry Software
144
7 Profiles of Key Flow Cytometry Companies …………………………….. 146
7.1 Agilent/Dako …………………………………………………………………………… 147
7.2 Amphasys ……………………………………………………………………………….. 150
7.3 Apogee Flow Systems ……………………………………………………………… 152
7.4 Applied Cytometry ………………………………………………………………….. 153
7.5 Astrolabe Diagnostics ……………………………………………………………… 154
7.6 Beckman Coulter Diagnostics …………………………………………………. 155
7.7 Becton, Dickinson and Company ……………………………………………. 156
7.8 BennuBio …………………………………………………………………………………. 158
7.9 bioMérieux Diagnostics ……………………………………………………………. 159
7.10 Bio-Rad Laboratories, Inc. …………………………………………………….. 162
7.11 Cytek Biosciences ………………………………………………………………… 165
7.12 Cytognos ……………………………………………………………………………… 167
7.13 Cytonome ……………………………………………………………………………. 168
7.14 De Novo Software ………………………………………………………………… 169
7.15 Gemini Bio ……………………………………………………………………………. 170
7.16 Kinetic River ………………………………………………………………………….. 172
7.17 Logos Biosystems ………………………………………………………………….. 173
7.18 Luminex Corp (DiaSorin) ……………………………………………………….. 174
7.19 Miltenyi Biotec ………………………………………………………………………. 176
7.20 Molecular Devices ……………………………………………………………….. 177
7.21 Nanion …………………………………………………………………………………. 179
7.22 NanoCellect Biotechnology …………………………………………………. 181
7.23 Omiq ……………………………………………………………………………………. 182
7.24 On-Chip Biotechnologies ……………………………………………………… 183
Profiles of Key Players
7.1 Agilent/Dako
7.2 Amphasys
7.3 Apogee Flow Systems
7.4 Applied Cytometry
7.5 Astrolabe Diagnostics
7.6 Beckman Coulter Diagnostics
7.7 Becton, Dickinson and Company
7.8 BennuBio
7.9 bioMérieux Diagnostics
7.10 Bio-Rad Laboratories, Inc.
7.11 Cytek Biosciences
7.12 Cytognos
7.13 Cytonome
7.14 De Novo Software
7.15 Gemini Bio
7.16 Kinetic River
7.17 Logos Biosystems
7.18 Luminex Corp (DiaSorin)
7.19 Miltenyi Biotec
7.20 Molecular Devices
7.21 Nanion
7.22 NanoCellect Biotechnology
7.23 Omiq
7.24 On-Chip Biotechnologies
7.25 Partek
7.26 Sartorius
7.27 SBT Instruments
7.28 Singleron Biotechnologies
7.29 Sony Biotechnology
7.30 Standard BioTools
7.31 Stratedigm
7.32 Sysmex
7.33 Sysmex Partec
7.34 Tecan
7.35 Tercen Data
7.36 Thermo Fisher Scientific Inc.
7.37 TissueGnostics
7.38 Union Biometrica
7.39 Verity Software House
7.40 Yokogawa Fluid Imaging Technologies
Table of Tables
Table 1 Some Characteristics Measured by Flow Cytometry …………………… 47
Table 2 Some Common Viability Assays ……………………………………………….. 50
Table 3 Oxidative Stress Related Diseases ……………………………………………. 59
Table 4 Important Signalling Pathways …………………………………………………. 61
Table 5 Market Players by Type ……………………………………………………………. 66
Table 6 Four Factors Driving Growth ……………………………………………………… 72
Table 7 Three Factors Limiting Growth ………………………………………………….. 77
Table 8 Global Market by Country/Region …………………………………………. 210
Table 9 Global Market by Product ……………………………………………………… 213
Table 10 Global Market by Application ………………………………………………. 219
Table 11 Global Market by Technology ………………………………………………. 225
Table 12 Reagent Market by Country …………………………………………………. 232
Table 13 Instrument Market by Country ………………………………………………. 234
Table 14 Services Market by Country ………………………………………………….. 236
Table 15 Software Market by Country …………………………………………………. 238
Table 16 Research Market by Country ………………………………………………… 241
Table 17 Clinical Market by Country …………………………………………………… 243
Table 18 Industrial Market by Country …………………………………………………. 245
Table 19 Other Application Market by Country…………………………………… 247
Table 20 Gel Market by Country …………………………………………………………. 250
Table 21 Bead Market by Country ………………………………………………………. 252
Table 22 Clinical Lab Fee Schedule …………………………………………………… 255
Table of Figures
Figure 1 Pharmaceutical Research Expenditures ($Billion) ……………………. 34
Figure 2 Oxidative Stress and Free Radical Toxicity ……………………………….. 59
Figure 3 FDA Cancer Drug Approvals …………………………………………………… 74
Figure 4 Immunotherapy vs Traditional …………………………………………………. 75
Figure 5 Growth rates of Flow Cytometry by Product Class …………………… 80
Figure 6 Market Size by Country ………………………………………………………….. 212
Figure 7 Global Market by Product – Base vs. Final Year ……………………… 214
Figure 8 Product Market Base Year …………………………………………………….. 215
Figure 9 Product Market Final Year ……………………………………………………… 216
Figure 10 Product Share by Year …………………………………………………………. 217
Figure 11 Product Segment Growth ……………………………………………………. 218
Figure 12 Global Market by Application – Base vs. Final Year ………………. 220
Figure 13 Application Market Base Year ……………………………………………… 221
Figure 14 Application Market Final Year ……………………………………………… 222
Figure 15 Application Share by Year …………………………………………………… 223
Figure 16 Application Segment Growth ……………………………………………… 224
Figure 17 Global Market by Technology – Base vs. Final Year ……………… 226
Figure 18 Technology Market Base Year ……………………………………………… 227
Figure 19 Technology Market Final Year ……………………………………………… 228
Figure 20 Technology Share by Year …………………………………………………… 229
Figure 21 Technology Segment Growth ……………………………………………… 230
Figure 22 Chart – Reagent Market Growth …………………………………………. 233
Figure 23 Chart Instrument Market Growth …………………………………………. 235
Figure 24 Chart – Services Market Growth ………………………………………….. 237
Figure 25 Chart – Software Market Growth …………………………………………. 239
Figure 26 Chart – Research Market Growth ………………………………………… 242
Figure 27 Chart Clinical Market Growth ………………………………………………. 244
Figure 28 Chart – Industrial Market Growth …………………………………………. 246
Figure 29 Chart – Other Application Market Growth …………………………… 248
Figure 30 Chart – Gel Market Growth …………………………………………………. 251
Figure 31 Chart Bead Market Growth …………………………………………………. 253
Figure 32 FDA Cancer Drug Approvals by Year ………………………………….. 401
Figure 33 Clinical Trials for Immunotherapy by Year …………………………….. 402
Figure 34 Share of Pharma R&D by Country ……………………………………….. 403
Since 2001 Howe Sound Research is a market research and consulting company based in Vancouver, British Columbia, Canada. We publish market research reports that address scientific industries with an emphasis on Biotechnology, Medical Imaging, Pharmaceutical and Clinical Diagnostic markets. We consider ourselves experts in these areas. This contrasts with the many research mills that produce canned reports on the Handbag market one day and the X-ray market the next.
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